Genetic Impact of Functional Single Nucleotide Polymorphisms in the 3′-UTR Region of the Chemoattractant Receptor Expressed on Th2 Cells (CRTH2) Gene on Asthma and Atopy in a Japanese Population

@article{Maeda2006GeneticIO,
  title={Genetic Impact of Functional Single Nucleotide Polymorphisms in the 3′-UTR Region of the Chemoattractant Receptor Expressed on Th2 Cells (CRTH2) Gene on Asthma and Atopy in a Japanese Population},
  author={Y. Maeda and N. Hizawa and D. Takahashi and Y. Fukui and S. Konno and M. Nishimura},
  journal={International Archives of Allergy and Immunology},
  year={2006},
  volume={142},
  pages={51 - 58}
}
  • Y. Maeda, N. Hizawa, +3 authors M. Nishimura
  • Published 2006
  • Biology, Medicine
  • International Archives of Allergy and Immunology
  • Background: The human chemoattractant receptor expressed on Th2 cells (CRTH2), the receptor for prostaglandin D2, induces cell migration in eosinophils, basophils, and Th2 cells. The gene encoding CRTH2 is located on chromosome 11q13. Several groups, including ours, have reported significant associations between this region and various traits associated with allergic diseases such as asthma and atopy. Two single nucleotide polymorphisms in the 3′-UTR of the CRTH2 gene (1544G→C and 1651G→A) are… CONTINUE READING
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