Genetic Identification of an On-Off Direction- Selective Retinal Ganglion Cell Subtype Reveals a Layer-Specific Subcortical Map of Posterior Motion

@article{Huberman2009GeneticIO,
  title={Genetic Identification of an On-Off Direction- Selective Retinal Ganglion Cell Subtype Reveals a Layer-Specific Subcortical Map of Posterior Motion},
  author={Andrew D Huberman and Wei Wei and Justin Blake Elstrott and Ben K. Stafford and Marla B Feller and Ben A Barres},
  journal={Neuron},
  year={2009},
  volume={62},
  pages={327-334}
}
Motion detection is an essential component of visual processing. On-Off direction-selective retinal ganglion cells (On-Off DSGCs) detect objects moving along specific axes of the visual field due to their precise retinal circuitry. The brain circuitry of On-Off DSGCs, however, is largely unknown. We report a mouse with GFP expressed selectively by the On-Off DSGCs that detect posterior motion (On-Off pDSGCs), allowing two-photon targeted recordings of their light responses and delineation of… CONTINUE READING
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