Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases.

  title={Genetic Heterogeneity in Therapy-Na{\"i}ve Synchronous Primary Breast Cancers and Their Metastases.},
  author={Charlotte K. Y. Ng and François-Cl{\'e}ment Bidard and Salvatore Piscuoglio and Felipe C Geyer and Raymond Lim and Ino de Bruijn and Ronglai Shen and Fresia Pareja and Samuel H. Berman and Lu Wang and J. Y. Pierga and Anne Vincent-Salomon and Agnes J. Viale and Larry Norton and Brigitte Sigal and Britta Weigelt and Paul Cottu and Jorge S Reis-Filho},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={23 15},
Purpose: Paired primary breast cancers and metachronous metastases after adjuvant treatment are reported to differ in their clonal composition and genetic alterations, but it is unclear whether these differences stem from the selective pressures of the metastatic process, the systemic therapies, or both. We sought to define the repertoire of genetic… CONTINUE READING