Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease.

  title={Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease.},
  author={Quentin M Anstee and Devanshi Seth and Christopher Paul Day},
  volume={150 8},
Genome-wide association studies and candidate gene studies have informed our understanding of factors contributing to the well-recognized interindividual variation in the progression and outcomes of alcoholic liver disease and nonalcoholic fatty liver disease. We discuss the mounting evidence for shared modifiers and common pathophysiological processes that contribute to development of both diseases. We discuss the functions of proteins encoded by risk variants of genes including patatin-like… CONTINUE READING
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