Genetic Engineering of Hematopoiesis for Targeted IFN-α Delivery Inhibits Breast Cancer Progression

  title={Genetic Engineering of Hematopoiesis for Targeted IFN-α Delivery Inhibits Breast Cancer Progression},
  author={Giulia Escobar and Davide Moi and Anna Ranghetti and Pinar Ozkal-Baydin and M. Squadrito and A. Kajaste-Rudnitski and A. Bondanza and Bernhard Gentner and M. De Palma and R. Mazzieri and L. Naldini},
  journal={Science Translational Medicine},
  pages={217ra3 - 217ra3}
  • Giulia Escobar, Davide Moi, +8 authors L. Naldini
  • Published 2014
  • Biology, Medicine
  • Science Translational Medicine
  • Inhibition of primary and metastatic breast cancer by targeted delivery of interferon-α by tumor-infiltrating monocytes. Toasting Tumor Immunotherapy Tumor immunotherapy is a promising new strategy for cancer treatment but is somewhat limited by the immunosuppressive nature of the tumor microenvironment. Type I interferons (IFNs) have been shown to promote tumor immunity, but systemic toxicity has limited their use. Genetic engineering of hematopoietic stem cells (HSCs) is one way to modulate… CONTINUE READING
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