Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes

@article{Lequime2016GeneticDP,
  title={Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes},
  author={S. Lequime and A. Fontaine and M. Ar Gouilh and Isabelle Moltini-Conclois and L. Lambrechts},
  journal={PLoS Genetics},
  year={2016},
  volume={12}
}
Due to their error-prone replication, RNA viruses typically exist as a diverse population of closely related genomes, which is considered critical for their fitness and adaptive potential. Intra-host demographic fluctuations that stochastically reduce the effective size of viral populations are a challenge to maintaining genetic diversity during systemic host infection. Arthropod-borne viruses (arboviruses) traverse several anatomical barriers during infection of their arthropod vectors that… Expand
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