Genetic Diversity in New Members of the Reticulocyte Binding Protein Family in Thai Plasmodium vivax Isolates

@inproceedings{Kosaisavee2012GeneticDI,
  title={Genetic Diversity in New Members of the Reticulocyte Binding Protein Family in Thai Plasmodium vivax Isolates},
  author={Varakorn Kosaisavee and Usa Lek-Uthai and Rossarin Suwanarusk and Anne Charlotte Gr{\"u}ner and Bruce D. Russell and François H Nosten and Laurent R{\'e}nia and Georges Snounou},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Plasmodium vivax merozoites specifically invade reticulocytes. Until recently, two reticulocyte-binding proteins (Pvrbp1 and Pvrbp2) expressed at the apical pole of the P. vivax merozoite were considered to be involved in reticulocyte recognition. The genome sequence recently obtained for the Salvador I (Sal-I) strain of P. vivax revealed additional genes in this family, and in particular Pvrbp2a, Pvrbp2b (Pvrbp2 has been renamed as Pvrbp2c) and two pseudogenes Pvrbp2d and Pvrbp3. It… CONTINUE READING