Genetic Dissection of the Tail Suspension Test: A Mouse Model of Stress Vulnerability and Antidepressant Response

@article{Liu2007GeneticDO,
  title={Genetic Dissection of the Tail Suspension Test: A Mouse Model of Stress Vulnerability and Antidepressant Response},
  author={Xiaoqing Liu and Devin Aldin Stancliffe and Samuel Wei Liang Lee and Shelly Mathur and Howard K. Gershenfeld},
  journal={Biological Psychiatry},
  year={2007},
  volume={62},
  pages={81-91}
}
BACKGROUND The tail suspension test (TST) is a mouse screening test for antidepressants. METHODS An F2 intercross was derived from NMRI and 129S6 inbred strains (n = 747). Mice underwent standardized TST with 2 sessions: (1) baseline and (2) imipramine (30 mg/kg, intraperitoneally) TST. RESULTS A whole genome scan of this intercross mapped significant basal TST quantitative trait loci (QTL) on chromosomes (chr) 5 (peak 61 cM, Lod 5.7), 12 (peak 43 cM, Lod 5.2), and 18 (peak 51 cM, Lod 3.0… CONTINUE READING
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