Genetic Dissection of the Function of Hindbrain Axonal Commissures

  title={Genetic Dissection of the Function of Hindbrain Axonal Commissures},
  author={Nicolas Renier and Martijn Schonewille and Fabrice Giraudet and Aleksandra Badura and Marc Tessier-Lavigne and Paul Avan and Chris I. De Zeeuw and Alain Ch{\'e}dotal},
  booktitle={PLoS biology},
In Bilateria, many axons cross the midline of the central nervous system, forming well-defined commissures. Whereas in mammals the functions of commissures in the forebrain and in the visual system are well established, functions at other axial levels are less clearly understood. Here, we have dissected the function of several hindbrain commissures using genetic methods. By taking advantage of multiple Cre transgenic lines, we have induced site-specific deletions of the Robo3 receptor. These… CONTINUE READING
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