Genetic Determinants of Vitamin D-Related Disorders; Focus on Vitamin D Receptor.

  title={Genetic Determinants of Vitamin D-Related Disorders; Focus on Vitamin D Receptor.},
  author={Mohamed Abouzid and Marta Karazniewicz-Lada and Franciszek K. Gł{\'o}wka},
  journal={Current drug metabolism},
  volume={19 12},
BACKGROUND The endocrine system of vitamin D is involved in an extensive variety of biological processes such as bone metabolism, regulation of cell proliferation and differentiation and modulation of the immune response. The active form of vitamin D, 25-hydroxyvitamin D, binds to vitamin D receptor (VDR) controlling the synthesis of many different proteins. Although numerous studies reported polymorphism in the VDR gene, the impact of the polymorphic alleles on VDR protein function remains… 

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