Genetic Determinants of UV-Susceptibility in Non-Melanoma Skin Cancer

  title={Genetic Determinants of UV-Susceptibility in Non-Melanoma Skin Cancer},
  author={Marleen M. Welsh and Margaret R. Karagas and Jacquelyn K. Kuriger and Andres E Houseman and Steven K. Spencer and A Elizabeth Perry and Heather H. Nelson},
  booktitle={PloS one},
A milieu of cytokines and signaling molecules are involved in the induction of UV-induced immune suppression and thus the etiology of non-melanoma skin cancer (NMSC). Targeting the UV-induced immunosuppression pathway, and using a large population based study of NMSC, we have investigated the risk associated with functional variants in 10 genes (IL10, IL4, IL4R, TNF, TNFR2, HTR2A, HRH2, IL12B, PTGS2, and HAL). The most prominent single genetic effect was observed for IL10. There was increasing… CONTINUE READING
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Keratinocyte Carcinomas (Basal and Squamous Cell Carcinomas of the Skin)

MR Karagas, Martin A. Weinstock, Heather H. Nelson
Schottenfeld DaJFF, ed. Cancer Epidemiology and Prevention, • 2006
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