Genetic Determinants of Severity of Acute Withdrawal From Diazepam in Mice: Commonality With Ethanol and Pentobarbital

@article{Metten1999GeneticDO,
  title={Genetic Determinants of Severity of Acute Withdrawal From Diazepam in Mice: Commonality With Ethanol and Pentobarbital},
  author={P. Metten and J. Crabbe},
  journal={Pharmacology Biochemistry and Behavior},
  year={1999},
  volume={63},
  pages={473-479}
}
  • P. Metten, J. Crabbe
  • Published 1999
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
Potentially life-threatening seizures can occur following withdrawal from benzodiazepines, ethanol, or barbiturates. In animals, withdrawal severity has been shown to be partially genetically determined for each drug class. Susceptibility to these drugs is partially determined by common genetic factors, but the evidence is conflicting. We tested the hypothesis that acute benzodiazepine withdrawal convulsions are influenced by at least some genes that also affect withdrawal from ethanol and… Expand
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