Genetic Determinants of Serum Testosterone Concentrations in Men

@article{Ohlsson2011GeneticDO,
  title={Genetic Determinants of Serum Testosterone Concentrations in Men},
  author={C. Ohlsson and H. Wallaschofski and K. Lunetta and L. Stolk and J. Perry and A. Koster and A. Petersen and J. Eriksson and T. Lehtim{\"a}ki and I. Huhtaniemi and G. Hammond and M. Maggio and A. Coviello and L. Ferrucci and M. Heier and A. Hofman and K. Holliday and J. Jansson and M. K{\"a}h{\"o}nen and D. Karasik and M. Karlsson and D. Kiel and Yongmei Liu and {\"O}. Ljunggren and M. Lorentzon and L. Lyytik{\"a}inen and T. Meitinger and D. Mellstr{\"o}m and D. Melzer and I. Miljkovic and M. Nauck and M. Nilsson and B. Penninx and S. Pye and R. Vasan and M. Reincke and F. Rivadeneira and A. Tajar and A. Teumer and A. Uitterlinden and J. Ulloor and J. Viikari and U. V{\"o}lker and H. V{\"o}lzke and H. Wichmann and Tsung-Sheng Wu and W. V. Zhuang and E. Ziv and Frederick C. W. Wu and O. Raitakari and A. Eriksson and M. Bidlingmaier and T. Harris and A. Murray and F. de Jong and J. Murabito and S. Bhasin and L. Vandenput and R. Haring},
  journal={PLoS Genetics},
  year={2011},
  volume={7}
}
Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum… Expand
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Mendelian randomization suggests non‐causal associations of testosterone with cardiometabolic risk factors and mortality
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