Genetic Determinants of Predisposition to Bronchial Asthma

  title={Genetic Determinants of Predisposition to Bronchial Asthma},
  author={Tatanya E. Ivaschenko and O. G. Sideleva and Maya A Petrova and T. E. Gembitskaya and Artem Orlov and Vladislav S. Baranov},
  journal={Russian Journal of Genetics},
The ratio between the normal (+) and null (0) alleles of the genes encoding glutatione S-transferases M1 (GSTM1) and T1 (GSTT1) were studied in normal individuals from northwestern Russia (control group) and in patients with bronchial asthma (BA). The frequency of the GSTM1 0/0 genotype in the population sample was statistically significantly lower (37.8%) than in the BA patients (82.1%; χ2 = 16.8;P< 0.001; Wχ2 = 15.7; α = 0.01). For the GSTT1 gene, similar data were obtained. The frequency of… CONTINUE READING
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