Genetic Determinants of Depression: Recent Findings and Future Directions
@article{Dunn2015GeneticDO, title={Genetic Determinants of Depression: Recent Findings and Future Directions}, author={E. Dunn and Ruth C Brown and Yael G Dai and J. Rosand and N. Nugent and A. Amstadter and J. Smoller}, journal={Harvard Review of Psychiatry}, year={2015}, volume={23}, pages={1–18} }
Learning ObjectivesAfter participating in this activity, learners should be better able to: 1. Evaluate current evidence regarding the genetic determinants of depression 2. Assess findings from studies of gene-environment interaction 3. Identify challenges to gene discovery in depression AbstractDepression is one of the most prevalent, disabling, and costly mental health conditions in the United States and also worldwide. One promising avenue for preventing depression and informing its clinical… CONTINUE READING
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References
SHOWING 1-10 OF 192 REFERENCES
The current state of play on the molecular genetics of depression.
- Biology, Medicine
- Psychological medicine
- 2013
- 68
Research review: gene-environment interaction research in youth depression - a systematic review with recommendations for future research.
- Psychology, Medicine
- Journal of child psychology and psychiatry, and allied disciplines
- 2011
- 53
Genetic risk profiles for depression and anxiety in adult and elderly cohorts
- Psychology, Medicine
- Molecular Psychiatry
- 2011
- 145
- PDF
Pharmacogenomic testing and personalized treatment of depression.
- Medicine
- Clinical chemistry
- 2014
- 37
- PDF
Overview of the Genetics of Major Depressive Disorder
- Psychology, Medicine
- Current psychiatry reports
- 2010
- 296
Gene–environment interactions: early life stress and risk for depressive and anxiety disorders
- Psychology, Medicine
- Psychopharmacology
- 2010
- 191
A Genome-Wide Association Study of Depressive Symptoms
- Psychology, Medicine
- Biological Psychiatry
- 2013
- 145
- PDF
Discovering Endophenotypes for Major Depression
- Psychology, Medicine
- Neuropsychopharmacology
- 2004
- 984
- PDF
The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis
- Psychology, Medicine
- Molecular Psychiatry
- 2008
- 500
- PDF
Etiology of depression: genetic and environmental factors.
- Medicine, Biology
- The Psychiatric clinics of North America
- 2012
- 155