Genetic Determinants of Cell Size at Birth and Their Impact on Cell Cycle Progression in Saccharomyces cerevisiae

@inproceedings{Truong2013GeneticDO,
  title={Genetic Determinants of Cell Size at Birth and Their Impact on Cell Cycle Progression in Saccharomyces cerevisiae},
  author={Sandra K. Truong and Ryan F. McCormick and Michael Polymenis},
  booktitle={G3},
  year={2013}
}
In most cases, cells must increase their size before they can divide. Hence, a small size has been used often as a phenotype for mutants that accelerate initiation of division, such as the celebrated WHI mutants of budding yeast. Recently, we measured the DNA content of all nonessential gene deletion strains in Saccharomyces cerevisiae. Surprisingly, there was little, if any, correlation between mean cell size and cell-cycle progression. Here, we examine this issue further, providing the first… CONTINUE READING