Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy

@inproceedings{Chiang2015GeneticDO,
  title={Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy},
  author={Chin-Wei Chiang and Hsueh-Te Lee and Der-Cherng Tarng and K Kuo and Li-Ching Cheng and Tzong-Shyuan Lee},
  booktitle={Mediators of inflammation},
  year={2015}
}
Soluble epoxide hydrolase (sEH) is abundantly expressed in kidney and plays a potent role in regulating inflammatory response in inflammatory diseases. However, the role of sEH in progression of chronic kidney diseases such as obstructive nephropathy is still elusive. In current study, wild-type (WT) and sEH deficient (sEH (-/-)) mice were subjected to the unilateral ureteral obstruction (UUO) surgery and the kidney injury was evaluated by histological examination, western blotting, and ELISA… CONTINUE READING
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