Genetic Deletion of RALA and RALB Small GTPases Reveals Redundant Functions in Development and Tumorigenesis

@article{Peschard2012GeneticDO,
  title={Genetic Deletion of RALA and RALB Small GTPases Reveals Redundant Functions in Development and Tumorigenesis},
  author={Pascal Peschard and Afshan Mccarthy and Val{\'e}rie Leblanc-Dominguez and Maggie Yeo and Sabrina Guichard and Gordon Stamp and Christopher J. Marshall},
  journal={Current Biology},
  year={2012},
  volume={22},
  pages={2063-2068}
}
RAL small GTPases, encoded by the Rala and Ralb genes, are members of the RAS superfamily of small GTPases and can act as downstream effectors of RAS [1]. Although highly similar, distinct functions have been identified for RALA and RALB: RALA has been implicated in epithelial cell polarity [2], insulin secretion [3], GLUT4 translocation [4, 5], neurite branching, and neuronal polarity [6, 7], and RALB in tumor cell survival [8], migration/invasion [9-12], TBK1 activation [13], and autophagy… CONTINUE READING