Genetic Control of the Immune Response

  title={Genetic Control of the Immune Response},
  author={Peter Lonai and Hugh O Mcdevitt},
  journal={The Journal of Experimental Medicine},
  pages={977 - 994}
In vitro antigen-induced tritiated thymidine uptake has been used to study the response of sensitized lymphocytes to (T,G)-A--L, (H,G)-A--L, and (Phe,G)-A--L in responder and nonresponder strains of mice. The reaction is T-cell and macrophage dependent. Highly purified T cells (91% Thy 1.2 positive) are also responsive, suggesting that this in vitro lymphocyte transformation system is not B-cell dependent. Lymphocytes from high and low responder mice stimulated in vitro react as responders and… CONTINUE READING


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