Genetic Characters of Human Γ-globulins in Myeloma Proteins

  title={Genetic Characters of Human Γ-globulins in Myeloma Proteins},
  author={Morten Harboe and Carsten Osterland and Mart Mannik and Henry G. Kunkel},
  journal={The Journal of Experimental Medicine},
  pages={719 - 738}
The genetic factors Gm(a), Gm(b), Gm(x), and Inv(a), Inv(b) described for normal human gamma-globulin were all found in different myeloma proteins. A single myeloma protein never contained more than one product of alternate alleles even in heterozygous individuals. However, factors determined by the two different loci were often found in the same myeloma protein. The Gm(a) character of the myeloma protein parallelled that of the normal gamma-globulin of the same serum in most cases. In contrast… CONTINUE READING
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On structural and functional relations between antibodies and proteins of the gamma-system.

Proceedings of the National Academy of Sciences of the United States of America • 1962

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