Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.

@article{Milaneschi2017GeneticAO,
  title={Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.},
  author={Yuri Milaneschi and Femke Lamers and Wouter J. Peyrot and Bernhard T. Baune and Gerome Breen and Abbas Dehghan and Andreas J Forstner and Hans J{\"o}rgen Grabe and Georg Homuth and C Kan and Cathryn M. Lewis and Niamh Mullins and Matthias Nauck and Giorgio Pistis and Martin Preisig and Margarita Rivera and Marcella Rietschel and Fabian Streit and Jana Strohmaier and Alexander Teumer and Sandra Van der Auwera and Naomi R Wray and Dorret I. Boomsma and Brenda W J H Penninx},
  journal={JAMA psychiatry},
  year={2017},
  volume={74 12},
  pages={
          1214-1225
        }
}
Importance The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode. Objective To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP… CONTINUE READING

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