Genetic Association Analysis of 300 Genes Identifies a Risk Haplotype in SLC18A2 for Post-traumatic Stress Disorder in Two Independent Samples

@article{Solovieff2014GeneticAA,
  title={Genetic Association Analysis of 300 Genes Identifies a Risk Haplotype in SLC18A2 for Post-traumatic Stress Disorder in Two Independent Samples},
  author={Nadia Solovieff and Andrea L Roberts and Andrew Ratanatharathorn and Michelle Haloosim and Immaculata De Vivo and Anthony P. King and Israel Liberzon and Allison E Aiello and Monica Uddin and Derek E. Wildman and Sandro Galea and Jordan W. Smoller and Shaun M Purcell and Karestan Koenen},
  journal={Neuropsychopharmacology},
  year={2014},
  volume={39},
  pages={1872-1879}
}
The genetic architecture of post-traumatic stress disorder (PTSD) remains poorly understood with the vast majority of genetic association studies reporting on single candidate genes. We conducted a large genetic study in trauma-exposed European-American women (N=2538; 845 PTSD cases, 1693 controls) by testing 3742 SNPs across more than 300 genes and conducting polygenic analyses using results from the Psychiatric Genome-Wide Association Studies Consortium (PGC). We tested the association… CONTINUE READING