Genetic Architecture of Familial Hypercholesterolaemia

  title={Genetic Architecture of Familial Hypercholesterolaemia},
  author={Mahtab Sharifi and Marta Futema and Devaki R. Nair and Steve E Humphries},
  booktitle={Current cardiology reports},
PURPOSE OF REVIEW Familial hypercholesterolaemia (FH) is an inherited disorder of low-density lipoprotein cholesterol (LDL-C) which is characterised by a raised cholesterol level from birth and a high risk of premature coronary heart disease. In this paper, we review the genetic basis of FH and its impact on the clinical presentation. RECENT FINDINGS… CONTINUE READING