Genetic Approaches to Investigate the Role of CREB in Neuronal Plasticity and Memory

@article{Barco2011GeneticAT,
  title={Genetic Approaches to Investigate the Role of CREB in Neuronal Plasticity and Memory},
  author={Angel Barco and H{\'e}l{\`e}ne Marie},
  journal={Molecular Neurobiology},
  year={2011},
  volume={44},
  pages={330-349}
}
In neurons, the convergence of multiple intracellular signaling cascades leading to cAMP-responsive element-binding protein (CREB) activation suggests that this transcription factor plays a critical role in integrating different inputs and mediating appropriate neuronal responses. The nature of this transcriptional response depends on both the type and strength of the stimulus and the cellular context. CREB-dependent gene expression has been involved in many different aspects of nervous system… CONTINUE READING