Genetic Analysis of Rare Disorders: Bayesian Estimation of Twin Concordance Rates

Abstract

Twin concordance rates provide insight into the possibility of a genetic background for a disease. These concordance rates are usually estimated within a frequentistic framework. Here we take a Bayesian approach. For rare diseases, estimation methods based on asymptotic theory cannot be applied due to very low cell probabilities. Moreover, a Bayesian… (More)
DOI: 10.1007/s10519-012-9547-9

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