Genetic Analysis of Bordetella pertussis Isolates from the 2008–2010 Pertussis Epidemic in Japan

@inproceedings{Miyaji2013GeneticAO,
  title={Genetic Analysis of Bordetella pertussis Isolates from the 2008–2010 Pertussis Epidemic in Japan},
  author={Yusuke Miyaji and Nao Otsuka and Hiromi Toyoizumi-Ajisaka and Keigo Shibayama and Kazunari Kamachi},
  booktitle={PloS one},
  year={2013}
}
A large pertussis epidemic occurred between 2008 and 2010 in Japan. To investigate epidemic strains, we analyzed 33 Bordetella pertussis isolates from the epidemic period by sequencing virulence-associated genes (fim3, ptxP, ptxA, and prn) and performing multilocus variable-number tandem repeat analysis (MLVA), and compared these results with those of 101 isolates from non-epidemic, earlier and later time periods. DNA sequencing of the fim3 allele revealed that the frequency of fim3B was 4.3… CONTINUE READING

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