Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

@inproceedings{Losada2015GeneticAU,
  title={Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence},
  author={Liliana Losada and Janyce A. Sugui and Michael A. Eckhaus and Yun C. Chang and Stephanie Mounaud and Abigail Figat and Vinita S. Joardar and Suman B. Pakala and Suchitra M. Pakala and Pratap Venepally and Natalie Fedorova and William C. Nierman and Kyung J. Kwon-Chung},
  booktitle={PLoS pathogens},
  year={2015}
}
Invasive aspergillosis (IA) due to Aspergillus fumigatus is a major cause of mortality in immunocompromised patients. The discovery of highly fertile strains of A. fumigatus opened the possibility to merge classical and contemporary genetics to address key questions about this pathogen. The merger involves sexual recombination, selection of desired traits, and genomics to identify any associated loci. We constructed a highly fertile isogenic pair of A. fumigatus strains with opposite mating… CONTINUE READING