Genetic Analyses in Consecutive Israeli Jewish Colorectal Cancer Patients

  title={Genetic Analyses in Consecutive Israeli Jewish Colorectal Cancer Patients},
  author={Herma H. Fidder and Ari{\'e} Figer and Ravit Geva and Dov Flex and Hagit Schayek and Benjamin Avidan and Simon Bar Meir and Eitan Friedman},
  journal={The American Journal of Gastroenterology},
OBJECTIVES:Two APC germline mutations, E1317Q and I1307K, have been linked to colorectal cancer (CRC) risk. Whereas the I1307K variant is almost exclusively encountered in (Ashkenazi) Jews, E1317Q is not restricted to certain ethnic populations. Data on its contribution to CRC risk in Jewish patients are sparse.AIMS:To assess the contribution of E1317Q to CRC development in the Jewish population.METHODS:A total of 538 consecutive Israeli Jewish CRC patients and 440 controls were genotyped for… CONTINUE READING

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