Genetic Alterations in Thyroid Carcinoma Associated with Familial Adenomatous Polyposis: Clinical Implications and Suggestions for Early Detection

@article{Cetta1998GeneticAI,
  title={Genetic Alterations in Thyroid Carcinoma Associated with Familial Adenomatous Polyposis: Clinical Implications and Suggestions for Early Detection},
  author={Francesco Cetta and Sylviane Olschwang and Margherita Petracci and Giulia Montalto and Claudio Baldi and Michele Zuckermann and Renato Mariani Costantini and Alfredo Fusco},
  journal={World Journal of Surgery},
  year={1998},
  volume={22},
  pages={1231-1236}
}
Germ-line mutations of the adenomatous polyposis ( APC ) gene, responsible for familial adenomatous polyposis (FAP) were analyzed in 15 patients with FAP-associated papillary thyroid carcinomas: 13 had the mutation between codons 778 and 1309 (exon 15), 1 at codon 593 (exon 14), and 1 at codon 140 (exon 3). Therefore APC gene mutations clustered in the genomic area associated with congenital hypertrophy of the retinal pigment epithelium (CHRPE) (codons 463–1387). Ocular patches were documented… CONTINUE READING

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