Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

@inproceedings{Quach2016GeneticAA,
  title={Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations},
  author={H{\'e}l{\`e}ne Quach and Maxime Rotival and Julien Pothlichet and Yong-Hwee Eddie Loh and Michael Dannemann and Nora Zidane and Guillaume Laval and Etienne Patin and Christine Harmant and Marie Lopez and Matthieu Deschamps and Nadia Naffakh and Darragh Duffy and Anja Coen and Geert G. Leroux-Roels and Fr{\'e}d{\'e}ric Cl{\'e}ment and Anne Boland and Jean-Francois Deleuze and Janet Kelso and Matthew L Albert and Llu{\'i}s Quintana-Murci},
  booktitle={Cell},
  year={2016}
}
Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the extent of population differences in immune responses and their genetic and evolutionary determinants remain undefined. Here, we characterized, using RNA sequencing, the transcriptional response of primary monocytes from Africans and Europeans to bacterial and viral stimuli-ligands activating Toll-like receptor pathways (TLR1/2, TLR4, and TLR7/8) and influenza virus-and mapped expression quantitative trait… CONTINUE READING
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