Genetic Abnormality of the Visual Pathways in a "White" Tiger
@article{Guillery1973GeneticAO, title={Genetic Abnormality of the Visual Pathways in a "White" Tiger}, author={Ray W. Guillery and Jon H. Kaas}, journal={Science}, year={1973}, volume={180}, pages={1287 - 1289} }
"White"tigers show an inherited reduction of pigment, produced by an autosomal recessive gene. The brain of one of these tigers shows an abnormality of the visual pathways similar to abnormalities that are associated with albinism in many other mammals. There is a close relationship between the reduced pigment formation, the pathway abnormality, and strabismus.
85 Citations
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The questions Ray posed and clues the authors have to date on the still‐elusive link between eye pigment and the proper balance of ipsilateral and contralateral retinal ganglion cell projections to the brain are presented.
References
SHOWING 1-10 OF 13 REFERENCES
Mutants with Abnormal Visual Pathways: An Explanation of Anomalous Geniculate Laminae
- BiologyScience
- 1971
Rats with geniculate laminae that run perpendicular to the lines of projection are described, and the chiasmatic course of axons arising in a patch of retinal ganglion cells is wrongly specified.
Anomalous Retinal Pathways in the Siamese Cat: An Inadequate Substrate for Normal Binocular Vision
- BiologyScience
- 1971
All major retinal pathways in the Siamese cat are abnormal, with almost total crossing of the projections to the pretectum and superior colliculus. These projections represent a marked disruption in…
Uncrossed Visual Pathways of Hooded and Albino Rats
- Biology, PsychologyScience
- 1965
The uncrossed visual pathways to the principal primary optic centers of hooded rats are substantially larger than those of albino rats. This provides an anatomical basis for the results of a recent…
The primary optic projections in the rabbit. An experimental degeneration study
- BiologyThe Journal of comparative neurology
- 1969
The brains of ten rabbits sacrificed 6–21 days after unilateral ocular enucleation were prepared by Nauta and Nissl methods and used to study the projection and terminal destribution of degenerating optic axons.
Some principles of organization in the dorsal lateral geniculate nucleus.
- BiologyBrain, behavior and evolution
- 1972
A comparative survey shows that lamination is a basic feature of the mammalian dorsal lateral geniculate nucleus. Relay laminae receive input from the retina, project to the cerebra
The laminar distribution of retinal fibers in the dorsal lateral geniculate nucleus of the cat: A new interpretation
- Biology
- 1970
The cell laminae of the lateral geniculate nucleus have been studied in relation to the retinogeniculate degeneration shown by the Nauta method and ventral to lamina A1 three laminaes have been defined.
An abnormal retinogeniculate projection in the albino ferret (Mustela furo).
- Biology, MedicineBrain research
- 1971
Ecology and Palaeoecology of Marine Environments
- Environmental Science, Geography
- 1972
__'._x t 7 of organisms in the North Sea, and he determines their influ...e^ . ..... : . nce on the marine sediment. 9Ze^.-as,;,^,; ^;'Functional morphology, mode of life and death of marine animals,…
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