Genetic Abnormality of the Visual Pathways in a "White" Tiger

  title={Genetic Abnormality of the Visual Pathways in a "White" Tiger},
  author={Ray W. Guillery and Jon H. Kaas},
  pages={1287 - 1289}
"White"tigers show an inherited reduction of pigment, produced by an autosomal recessive gene. The brain of one of these tigers shows an abnormality of the visual pathways similar to abnormalities that are associated with albinism in many other mammals. There is a close relationship between the reduced pigment formation, the pathway abnormality, and strabismus. 
Visual system anomalies in human ocular albinos.
Visually evoked potentials recorded from two types of human ocular albinos demonstrated significant hemispheric asymmetry following monocular stimulation. The asymmetry is indicative of
Congenitally abnormal visual pathways in mink (Mustela vison) with reduced retinal pigment
An abnormal retinogeniculate pathway has been found in all mink in which the retinal pigment is reduced and most of the abnormally routed nerve fibers arise in the temporal retina and cross in the chiasm, instead of staying ipsilateral as is normal.
Abnormal retino‐geniculate and geniculo‐cortical pathways in several genetically distinct color phases of the mink (Mustela vison)
Autoradiographic methods have been used to demonstrate the retino‐geniculate pathways, and retrograde degeneration or the retrograde transport of horseradish peroxidase has been used for the geniculo‐cortical pathways.
Asymmetric visually evoked potentials in human albinos: evidence for visual system anomalies.
Behavioral, anatomic, and electrophysiologic studies indicate that the nondecussated optic system is functionally incompetent and anatomically disorganized in albino animals, and the laminae of the dorsal lateral geniculate nucleus are abnormal.
Serendipity and the Siamese cat: the discovery that genes for coat and eye pigment affect the brain.
These experiments showed that the lack of normal levels of pigment in the retina in Siamese cats (and other hypopigmented mammals) was the critical factor in the misdirection of many of the projections of the retina to the brain, the nature of the projection error, and the developmental consequences of the relay of the misdirected retinal inputs to visual cortex.
Two distinct patterns of visual evoked response asymmetry in human albinism
Results are presented which confirm that in human albinos each cerebral hemisphere receives a predominantly monocular input from the contralateral eye, giving rise to an asymmetry of the visual
Retinogeniculate projections in the rabbits of the albino allelomorphic series
It has been found that albino and Himalayan rabbits, which both lack all melanin pigment in the eye, have a similar abnormality of the retinogeniculate pathway.
Siamese cats: abnormal responses of retinal ganglion cells.
Comparison of optic tract recordings in Siamese and ordinary cats reveals thatSiamese cats have a significantly lower percentage of Y-cells than of X-cells, and depressed responses to a contrast-reversal stimulus support the lower spatial contrast sensitivity demonstrated behaviorally by these animals.
Conversations with Ray Guillery on albinism: linking Siamese cat visual pathway connectivity to mouse retinal development
The questions Ray posed and clues the authors have to date on the still‐elusive link between eye pigment and the proper balance of ipsilateral and contralateral retinal ganglion cell projections to the brain are presented.


Mutants with Abnormal Visual Pathways: An Explanation of Anomalous Geniculate Laminae
Rats with geniculate laminae that run perpendicular to the lines of projection are described, and the chiasmatic course of axons arising in a patch of retinal ganglion cells is wrongly specified.
Anomalous Retinal Pathways in the Siamese Cat: An Inadequate Substrate for Normal Binocular Vision
All major retinal pathways in the Siamese cat are abnormal, with almost total crossing of the projections to the pretectum and superior colliculus. These projections represent a marked disruption in
Uncrossed Visual Pathways of Hooded and Albino Rats
  • R. Lund
  • Biology, Psychology
  • 1965
The uncrossed visual pathways to the principal primary optic centers of hooded rats are substantially larger than those of albino rats. This provides an anatomical basis for the results of a recent
The primary optic projections in the rabbit. An experimental degeneration study
The brains of ten rabbits sacrificed 6–21 days after unilateral ocular enucleation were prepared by Nauta and Nissl methods and used to study the projection and terminal destribution of degenerating optic axons.
Some principles of organization in the dorsal lateral geniculate nucleus.
A comparative survey shows that lamination is a basic feature of the mammalian dorsal lateral geniculate nucleus. Relay laminae receive input from the retina, project to the cerebra
The laminar distribution of retinal fibers in the dorsal lateral geniculate nucleus of the cat: A new interpretation
The cell laminae of the lateral geniculate nucleus have been studied in relation to the retinogeniculate degeneration shown by the Nauta method and ventral to lamina A1 three laminaes have been defined.
Ecology and Palaeoecology of Marine Environments
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