Genetic Abnormality of the Visual Pathways in a "White" Tiger

@article{Guillery1973GeneticAO,
  title={Genetic Abnormality of the Visual Pathways in a "White" Tiger},
  author={Ray W. Guillery and Jon H. Kaas},
  journal={Science},
  year={1973},
  volume={180},
  pages={1287 - 1289}
}
"White"tigers show an inherited reduction of pigment, produced by an autosomal recessive gene. The brain of one of these tigers shows an abnormality of the visual pathways similar to abnormalities that are associated with albinism in many other mammals. There is a close relationship between the reduced pigment formation, the pathway abnormality, and strabismus. 
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85 Citations
Background Citations
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Results Citations
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85 Citations

Visual system anomalies in human ocular albinos.
Visually evoked potentials recorded from two types of human ocular albinos demonstrated significant hemispheric asymmetry following monocular stimulation. The asymmetry is indicative of…
Congenitally abnormal visual pathways in mink (Mustela vison) with reduced retinal pigment
TLDR
An abnormal retinogeniculate pathway has been found in all mink in which the retinal pigment is reduced and most of the abnormally routed nerve fibers arise in the temporal retina and cross in the chiasm, instead of staying ipsilateral as is normal.
Abnormal retino‐geniculate and geniculo‐cortical pathways in several genetically distinct color phases of the mink (Mustela vison)
TLDR
Autoradiographic methods have been used to demonstrate the retino‐geniculate pathways, and retrograde degeneration or the retrograde transport of horseradish peroxidase has been used for the geniculo‐cortical pathways.
Retinal ganglion cells and optic decussation of white cats
Asymmetric visually evoked potentials in human albinos: evidence for visual system anomalies.
TLDR
Behavioral, anatomic, and electrophysiologic studies indicate that the nondecussated optic system is functionally incompetent and anatomically disorganized in albino animals, and the laminae of the dorsal lateral geniculate nucleus are abnormal.
Serendipity and the Siamese cat: the discovery that genes for coat and eye pigment affect the brain.
TLDR
These experiments showed that the lack of normal levels of pigment in the retina in Siamese cats (and other hypopigmented mammals) was the critical factor in the misdirection of many of the projections of the retina to the brain, the nature of the projection error, and the developmental consequences of the relay of the misdirected retinal inputs to visual cortex.
Two distinct patterns of visual evoked response asymmetry in human albinism
Results are presented which confirm that in human albinos each cerebral hemisphere receives a predominantly monocular input from the contralateral eye, giving rise to an asymmetry of the visual…
Retinogeniculate projections in the rabbits of the albino allelomorphic series
TLDR
It has been found that albino and Himalayan rabbits, which both lack all melanin pigment in the eye, have a similar abnormality of the retinogeniculate pathway.
Siamese cats: abnormal responses of retinal ganglion cells.
TLDR
Comparison of optic tract recordings in Siamese and ordinary cats reveals thatSiamese cats have a significantly lower percentage of Y-cells than of X-cells, and depressed responses to a contrast-reversal stimulus support the lower spatial contrast sensitivity demonstrated behaviorally by these animals.
Conversations with Ray Guillery on albinism: linking Siamese cat visual pathway connectivity to mouse retinal development
TLDR
The questions Ray posed and clues the authors have to date on the still‐elusive link between eye pigment and the proper balance of ipsilateral and contralateral retinal ganglion cell projections to the brain are presented.
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