Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia

@inproceedings{Lutz2011GeneticAO,
  title={Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia},
  author={Stefan Zolt{\'a}n Lutz and Anita M. Hennige and Susanne Feil and Andreas Peter and Andrea Gerling and J{\"u}rgen Machann and Stefan Martin Kroeber and Michaela Rath and Annette Sch{\"u}rmann and Cora Weigert and Hans-Ulrich H{\"a}ring and Robert Feil},
  booktitle={Diabetes},
  year={2011}
}
OBJECTIVE The nitric oxide/cGMP/cGMP-dependent protein kinase type I (cGKI) signaling pathway regulates cell functions that play a pivotal role in the pathogenesis of type 2 diabetes. However, the impact of a dysfunction of this pathway for glucose metabolism in vivo is unknown. RESEARCH DESIGN AND METHODS The expression of cGKI in tissues relevant to insulin action was analyzed by immunohistochemistry. The metabolic consequences of a genetic deletion of cGKI were studied in mice that express… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…