Genetic Ablation of Pannexin1 Protects Retinal Neurons from Ischemic Injury

@inproceedings{Dvoriantchikova2012GeneticAO,
  title={Genetic Ablation of Pannexin1 Protects Retinal Neurons from Ischemic Injury},
  author={Galina Dvoriantchikova and Dmitry Ivanov and David J. Barakat and Alexander Grinberg and Rong Wen and Vladlen Z Slepak and Valery I Shestopalov},
  booktitle={PloS one},
  year={2012}
}
Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play a key role in ischemic death of hippocampal neurons. Since retinal ganglion cells (RGCs) express high levels of Panx1 and are susceptible to ischemic induced injury, we hypothesized that Panx1 contributes to rapid and selective loss of these neurons in ischemia. To test this hypothesis, we induced experimental retinal… CONTINUE READING

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