Genetic/transgenic conditional expression of full-length and headless nonmuscle myosin-II molecules: head domain regulates localization in auditory neurons.


OBJECTIVE Human genetic mutations that affect the N-terminal head-domain of the nonmuscle myosin-II (MyoII) molecule can result in nonsyndromic sensorineural hearing loss but the underlying mechanism is unknown. Ultimately, MyoII must be appropriately localized in order to execute endogenous functions. The aim of the current study is to determine whether… (More)
DOI: 10.1016/j.ijporl.2013.02.011