Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene.

@article{Porcelli2010GeneticFA,
  title={Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene.},
  author={Damiano Porcelli and Marta Oliva and Serena Duchi and Dominga Latorre and Valeria Cavaliere and Paolo Barsanti and Gaetano Villani and Giuseppe Gargiulo and Corrado Caggese},
  journal={Mitochondrion},
  year={2010},
  volume={10 5},
  pages={433-48}
}
SCO proteins are copper-donor chaperones involved in the assembly of mitochondrial cytochrome c oxidase (COX). Mutations in the two human SCO-encoding genes, SCO1 and SCO2, produce tissue-specific COX deficiencies associated with distinct clinical phenotypes. Here, we report the identification and characterization of scox, the single Drosophila melanogaster SCO-encoding gene. Null mutations of the scox gene are associated with larval lethality, while mutations in its 5'UTR are associated with… CONTINUE READING
5 Citations
89 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 89 references

Similar Papers

Loading similar papers…