Genetic, epigenetic and posttranslational mechanisms of aging

@article{Robert2010GeneticEA,
  title={Genetic, epigenetic and posttranslational mechanisms of aging},
  author={L. Robert and J. Labat-Robert and A. Robert},
  journal={Biogerontology},
  year={2010},
  volume={11},
  pages={387-399}
}
Gerontological experimentation is and was always strongly influenced by “theories”. The early decades of molecular genetics inspired deterministic thinking, based on the “Central Dogma” (DNA → RNA → Proteins). With the progress of detailed knowledge of gene-function a much more complicated picture emerged. Regulation of gene-expression turned out to be a highly complicated process. Experimental gerontology produced over the last decades several “paradigms” incompatible with simple genetic… Expand
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