Genetic, Molecular and Clinical Determinants for the Involvement of Aldosterone and Its Receptors in Major Depression

@article{Murck2014GeneticMA,
  title={Genetic, Molecular and Clinical Determinants for the Involvement of Aldosterone and Its Receptors in Major Depression},
  author={Harald Murck and Matthias B{\"u}ttner and Tilo T. J. Kircher and Carsten Konrad},
  journal={Nephron Physiology},
  year={2014},
  volume={128},
  pages={17 - 25}
}
Major depression (MDE) has metabolic and neuroendocrine correlates, which point to a biological overlap between MDE and cardiovascular diseases. Whereas the hypothalamic-pituitary-adrenocortical axis has long been recognized for its involvement in depression, the focus was mostly on cortisol/corticosterone, whereas aldosterone appears to be the ‘forgotten' stress hormone. Part of the reason for this is that the receptors for aldosterone, the mineralocorticoid receptors (MR), were thought to be… Expand
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