Genetdes: automatic design of transcriptional networks

  title={Genetdes: automatic design of transcriptional networks},
  author={Guillermo Rodrigo and Javier Carrera and Alfonso Jaramillo},
  volume={23 14},
MOTIVATION The rational design of biological networks with prescribed functions is limited to gene circuits of a few genes. Larger networks involve complex interactions with many parameters and the use of automated computational tools can be very valuable. We propose a new tool to design transcriptional networks with targeted behavior that could be used to better understand the design principles of genetic circuits. RESULTS We have implemented a Simulated Annealing optimization algorithm that… CONTINUE READING
Highly Cited
This paper has 72 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 41 extracted citations

Prospects in the Cancer Arena

View 5 Excerpts
Method Support
Highly Influenced

Bacterial computing with engineered populations.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences • 2015
View 1 Excerpt

72 Citations

Citations per Year
Semantic Scholar estimates that this publication has 72 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 13 references

Bifurcation discovery tool

M. B. Elowitz, S. Leibler
Bioinformatics • 2005

Design of genetic networks with specified functions by evolution in silico.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 2 Excerpts

On schemes of combinatorial transcription logic.

Proceedings of the National Academy of Sciences of the United States of America • 2003