Genetdes: automatic design of transcriptional networks

@article{Rodrigo2007GenetdesAD,
  title={Genetdes: automatic design of transcriptional networks},
  author={Guillermo Rodrigo and Javier Carrera and Alfonso Jaramillo},
  journal={Bioinformatics},
  year={2007},
  volume={23 14},
  pages={
          1857-8
        }
}
MOTIVATION The rational design of biological networks with prescribed functions is limited to gene circuits of a few genes. Larger networks involve complex interactions with many parameters and the use of automated computational tools can be very valuable. We propose a new tool to design transcriptional networks with targeted behavior that could be used to better understand the design principles of genetic circuits. RESULTS We have implemented a Simulated Annealing optimization algorithm that… CONTINUE READING
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