Genesis of host IgE competence: perinatal IgE tolerance induced by IgE processed and presented by IgE Fc receptor (CD23)‐bearing B cells

  title={Genesis of host IgE competence: perinatal IgE tolerance induced by IgE processed and presented by IgE Fc receptor (CD23)‐bearing B cells},
  author={S S Chen},
  journal={European Journal of Immunology},
  • S. S. Chen
  • Published 1 February 1992
  • Biology, Medicine
  • European Journal of Immunology
A murine model for studying life‐long IgE tolerance was previously developed in this laboratory by perinatal IgE injection into neonates. Herein, we demonstrated that normal and immortal CD23+ B cell lines presented processed IgE via CD23‐mediated endocytic pathway and triggered perinatal IgE tolerance. The observations were as followed: (a) CD23 on normal B cells or B cell hybridomas mediated IgE‐dependent perinatal IgE tolerance and total IgE deficiency; and lack of either antigen‐specific… 

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