Genesis of a novel human sequence from the protamine PRM1 gene.

@article{Kramer1998GenesisOA,
  title={Genesis of a novel human sequence from the protamine PRM1 gene.},
  author={J. A. Kramer and Stephen A. Krawetz},
  journal={Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology},
  year={1998},
  volume={120 3},
  pages={467-73}
}
The members of the male haploid expressed protamine 1 (PRM1)-->protamine 2 (PRM2)-->transition protein 2 (TNP2) locus exist as a single, coordinately expressed genic domain. Previous analysis has revealed that the genes within the human PRM1-->PRM2-->TNP2 domain are inter-related, as they share significant sequence similarity at both the nucleotide and amino acid levels. Analysis described here supports the view that a fourth candidate coding region, gene4/Prm3, was derived from PRM1 during the… CONTINUE READING