Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia

@article{Li2004GenesisOA,
  title={Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia},
  author={Keng Sheng Li and Yi Guan and Jianmin Wang and Gavin J D Smith and Ke ming Xu and Lian Duan and A. P. Rahardjo and Pilaipan Puthavathana and Chantanee Buranathai and Tho Dang Nguyen and A. T. S. Estoepangestie and Arunee Chaisingh and Prasert Auewarakul and Hoang Thuy Long and Nguyen Thi Hong Hanh and Richard R. J. Webby and Leo Lit Man Poon and Hongzhi Chen and Kennedy Francis Shortridge and Kwok - Yung Yuen and Robert James Webster and Joseph S. M. Peiris},
  journal={Nature},
  year={2004},
  volume={430},
  pages={209-213}
}
A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2–4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a… CONTINUE READING
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