• DOI:10.1038/nature02746
Corpus ID: 4410379

Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia

@article{Li2004GenesisOA,
  title={Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia},
  author={K. S. Li and Yiyuan Guan and Jd Wang and Gavin J D Smith and Kai Xu and Lilan Duan and Adi Prijo Rahardjo and Pilaipan Puthavathana and Chantanee Buranathai and Tho Dang Nguyen and A. T. Soelih Estoepangestie and Arunee Chaisingh and Prasert Auewarakul and Hoang Thuy Long and Nguyen Thi Hanh and Richard John Webby and Leo Lit Man Poon and Hongzhi Chen and Kennedy F. Shortridge and K. Y. Yuen and Robert G. Webster and Joseph Sriyal Malik Peiris},
  journal={Nature},
  year={2004},
  volume={430},
  pages={209-213}
}

K. S. Li, Yiyuan Guan, +19 authors Joseph Sriyal Malik Peiris

Published 2004

Biology, Medicine

Nature

A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2–4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a… CONTINUE READING

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