Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia

@article{Li2004GenesisOA,
  title={Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia},
  author={K. S. Li and Yi Guan and Jd Wang and G J D Smith and K. M. Xu and Lian Duan and Adi Prijo Rahardjo and Pilipan Puthavathana and Chantanee Buranathai and T. D. Nguyen and A. T. S. Estoepangestie and Arunee Chaisingh and Prasert Auewarakul and HT Long and Nguyễn Thị Hồng Hạnh and Richard J. Webby and Leo L. M. Poon and Hongzhi Chen and Kennedy F. Shortridge and Kwok Yung Yuen and R. G. Webster and J. S. Malik Peiris},
  journal={Nature},
  year={2004},
  volume={430},
  pages={209-213}
}
A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2–4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a… 
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