Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia

@article{Li2004GenesisOA,
  title={Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia},
  author={K. Li and Y. Guan and J. Wang and G. Smith and K. Xu and L. Duan and A. Rahardjo and P. Puthavathana and Chantanee Buranathai and T. Nguyen and A. T. Estoepangestie and A. Chaisingh and P. Auewarakul and H. T. Long and N. T. Hanh and R. Webby and L. L. Poon and H. Chen and K. Shortridge and K. Y. Yuen and R. G. Webster and J. Peiris},
  journal={Nature},
  year={2004},
  volume={430},
  pages={209-213}
}
  • K. Li, Y. Guan, +19 authors J. Peiris
  • Published 2004
  • Biology, Medicine
  • Nature
  • A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2–4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a… CONTINUE READING
    1,249 Citations

    Figures, Tables, and Topics from this paper

    Double introduction of highly pathogenic H5N1 avian influenza virus into France in early 2006
    • 66
    • Highly Influenced
    • PDF
    Emergence and predominance of an H5N1 influenza variant in China
    • 312
    • PDF
    Molecular epidemiology of H5N1 avian influenza.
    • 73
    • PDF
    Origin and evolution of highly pathogenic H5N1 avian influenza in Asia
    • 281
    • PDF
    Highly pathogenic H5N1 avian influenza virus: cause of the next pandemic?
    • M. Pappaioanou
    • Biology, Medicine
    • Comparative immunology, microbiology and infectious diseases
    • 2009
    • 43
    Evolution of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam between 2001 and 2007
    • 118
    • PDF
    The emergence and diversification of panzootic H5N1 influenza viruses.
    • 85
    Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control.
    • H. Chen, G. Smith, +25 authors Y. Guan
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2006
    • 626
    • PDF
    Characterization of highly pathogenic H5N1 avian influenza viruses isolated from poultry markets in central China.
    • 33
    • Highly Influenced

    References

    SHOWING 1-10 OF 36 REFERENCES
    H5N1 influenza: a protean pandemic threat.
    • Y. Guan, L. Poon, +10 authors J. Peiris
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2004
    • 400
    • PDF
    Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR
    • 367
    • PDF
    Characterization of avian H5N1 influenza viruses from poultry in Hong Kong.
    • 575
    • PDF
    H 5 N 1 influenza : A protean pandemic threat
    • 47
    • PDF
    Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome.
    • 1,016
    • PDF
    Molecular characterization of H9N2 influenza viruses: were they the donors of the "internal" genes of H5N1 viruses in Hong Kong?
    • 623
    • PDF