Genesis of Sindbis virus by in vivo recombination of nonreplicative RNA precursors.

@article{Raju1995GenesisOS,
  title={Genesis of Sindbis virus by in vivo recombination of nonreplicative RNA precursors.},
  author={Ramaswamy Raju and Sandhya Subramaniam and M Hajjou},
  journal={Journal of virology},
  year={1995},
  volume={69 12},
  pages={7391-401}
}
Genetically engineered RNA transcripts coding for various Sindbis virus (SIN) genes were used to study structure and sequence requirements of RNA recombination in BHK cells. Three different groups of RNA transcripts were made: (i) RNAs which retain the ability to replicate and which carry sequences coding for either viral polymerase or viral structural proteins; (ii) RNAs which lack the complete 3' end of the SIN genome and thus are incapable of replicating; and (iii) RNAs which lack the… CONTINUE READING
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