Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model

@article{Hromas1999GenesisAW,
  title={Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model},
  author={Robert Hromas and Honggang Ye and Michael J. Spinella and Ethan Dmitrovsky and Dawei Xu and Robert H. Costa},
  journal={Cell and Tissue Research},
  year={1999},
  volume={297},
  pages={371-382}
}
A novel repressor of the Winged Helix (formerly HNF-3/Forkhead) transcriptional regulatory family, termed Genesis (also called HFH2), was previously found to be exclusively expressed in primitive embryonic cell lines. In this study in situ cRNA hybridization experiments revealed that Genesis was expressed during embryogenesis only in developing neural crest cells. Its expression diminished upon their terminal differentiation into sympathetic and parasympathetic neurons. Based on that finding… CONTINUE READING
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