Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model

@article{Hromas1999GenesisAW,
  title={Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model},
  author={R. Hromas and H. Ye and M. Spinella and E. Dmitrovsky and D. Xu and R. Costa},
  journal={Cell and Tissue Research},
  year={1999},
  volume={297},
  pages={371-382}
}
  • R. Hromas, H. Ye, +3 authors R. Costa
  • Published 1999
  • Biology, Medicine
  • Cell and Tissue Research
  • Abstract A novel repressor of the Winged Helix (formerly HNF-3/Forkhead) transcriptional regulatory family, termed Genesis (also called HFH2), was previously found to be exclusively expressed in primitive embryonic cell lines. In this study in situ cRNA hybridization experiments revealed that Genesis was expressed during embryogenesis only in developing neural crest cells. Its expression diminished upon their terminal differentiation into sympathetic and parasympathetic neurons. Based on that… CONTINUE READING
    58 Citations
    Overexpression of the transcriptional repressor FoxD3 prevents neural crest formation in Xenopus embryos
    • 111
    • Highly Influenced
    Zebrafish Foxd3 is required for development of a subset of neural crest derivatives.
    • 126
    Zebrafish foxd3 is selectively required for neural crest specification, migration and survival.
    • 156
    • PDF
    Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo.
    • 328
    • PDF

    References

    SHOWING 1-10 OF 80 REFERENCES
    Genesis, a Winged Helix Transcriptional Repressor with Expression Restricted to Embryonic Stem Cells*
    • 165
    • PDF
    Expression of the c-ret proto-oncogene during mouse embryogenesis.
    • 801
    • PDF
    Molecular cloning of tyrosine kinases in the early Xenopus embryo: Identification of eck‐related genes expressed in cranial neural crest cells of the second (Hyoid) Arch
    • A. Brändli, M. Kirschner
    • Medicine, Biology
    • Developmental dynamics : an official publication of the American Association of Anatomists
    • 1995
    • 38