Genes with greater up-regulation in the fracture callus of older rats with delayed healing.

@article{Meyer2007GenesWG,
  title={Genes with greater up-regulation in the fracture callus of older rats with delayed healing.},
  author={Martha H. Meyer and R. A. Meyer},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2007},
  volume={25 4},
  pages={488-94}
}
The rate of bone formation to bridge a fracture gap slows with age. To explore potential pathogenic mechanisms and possible negative-feedback responses by the skeleton to this reduced rate of healing, mRNA transcripts up-regulated more and/or longer were studied in older rats with delayed healing. Female rats at 6 (young), 26 (adult), and 52 (old) weeks of age received unilateral diaphyseal femoral fractures with intramedullary rod stabilization. At 0, 0.4, 1, 2, 4, and 6 weeks after fracture… CONTINUE READING

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