Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.

@article{Cottrez2015GenesSM,
  title={Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.},
  author={Françoise Cottrez and Elodie Boitel and Claude Auriault and Pierre Aeby and Herv{\'e} Groux},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2015},
  volume={29 4},
  pages={787-802}
}
Analysis of genes modulated during the sensitization process either on mice (LLNA) or human (blisters) combined with data mining has allowed the definition of a comprehensive panel of sensitization biomarkers. This set of genes includes already identified markers such as the ARE family and others not yet associated with the sensitization process (the so-called SENS-IS gene subset). The expression of this set of genes has been measured on reconstituted human epidermis models (Episkin) exposed to… CONTINUE READING
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