Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion

@article{2010GenesRF,
  title={Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion},
  author={Lu-Lu Shen 沈露露 and 杜敏 MinDu and Xing-Feng Lin 林兴凤 and 蔡婷 TingCai and Da-Yong Wang 王大勇},
  journal={Neuroscience Bulletin},
  year={2010},
  volume={26},
  pages={91-103}
}
To investigate the interaction between the genes required for the functions of AWA olfactory neuron and insulin/IGF signaling in regulating the longevity of nematode Caenorhabditis elegans (C. elegans). The mutants that had loss-of-function mutation of the genes required for AWA, AWC, ASE, and AFD sensory neurons were employed. Lifespan, the speed of pharynx pumping, the intestinal autofluorescence, the dauer formation, and the brood size were examined. Rescue experiments were performed to… Expand

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