Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex

@article{Blanden1975GenesRF,
  title={Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex},
  author={Robert V. Blanden and Peter C. Doherty and M C Dunlop and Ian D Gardner and Rolf Martin Zinkernagel and Chella S. David},
  journal={Nature},
  year={1975},
  volume={254},
  pages={269-270}
}
EVIDENCE is mounting that in mice, certain specific immunological effector functions of thymus-derived (T) lymphocytes are efficient only when donors of T cells and the cells with which they interact have at least a part of the H-2 gene complex in common1–8. Examples include T helper function in vivo and in vitro1–3, cytotoxicity mediated by T cells against virus-infected4–6 or TNP-modified7 target cells in vitro, immunopathology mediated by T cells4, or protection against bacterial8 and viral… CONTINUE READING

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