Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants

@article{Huang2008GenesRT,
  title={Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants},
  author={Lingkang Huang and Alexandra N. Heinloth and Zhao-Bang Zeng and Richard S. Paules and Pierre R. Bushel},
  journal={BMC Genomics},
  year={2008},
  volume={9},
  pages={288 - 288}
}
Some of the biochemical events that lead to necrosis of the liver are well-known. However, the pathogenesis of necrosis of the liver from exposure to hepatotoxicants is a complex biological response to the injury. We hypothesize that gene expression profiles can serve as a signature to predict the level of necrosis elicited by acute exposure of rats to a variety of hepatotoxicants and postulate that the expression profiles of the predictor genes in the signature can provide insight to some of… CONTINUE READING

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