Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids

  title={Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids},
  author={Russell D. Salter and David N. Howell and Dr. Peter Cresswell},
Regulation of HLA class I and class II antigen expression was studied in hybrids of human T and B lymphoblastoid cell lines (LCL). The T-LCL CEMR.3 expresses no HLA class II antigens. It expresses little total HLA class I antigen and no HLA-B antigens. The B-LCL 721.174 is a radiation-induced variant immunoselected for loss of class II antigen expression. In addition to showing a deletion of all HLA-DR and DQ structural genes, 721.174 expresses no HLA-B antigens and a decreased level of HLA-A… CONTINUE READING
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