Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.

Abstract

Human cancer cells frequently have regions of their DNA hypermethylated, which results in transcriptional silencing of affected genes and promotion of tumor formation. However, it is still unknown whether cancer-associated aberrant DNA methylation is targeted to specific genomic regions, whether this methylation also occurs in noncancerous cells, and… (More)
DOI: 10.1172/JCI43169

Topics

3 Figures and Tables

Cite this paper

@article{Steine2011GenesMB, title={Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.}, author={Eveline J. Steine and Mathias Ehrich and George W. Bell and Arjun Raj and Seshamma T Reddy and Alexander van Oudenaarden and Rudolf Jaenisch and Heinz G. Linhart}, journal={The Journal of clinical investigation}, year={2011}, volume={121 5}, pages={1748-52} }